TL;DR: Agentic workloads are becoming a major source of vLLM traffic. Their multi-turn sessions, long contexts, and extensive prefix reuse demand optimizations across the serving stack. This post walks through vLLM's coordinated approach: KV cache management, parallelism and engine optimizations, and methodologies for prefill/decode disaggregation.

Measured on AgentX, SemiAnalysis's public agentic benchmark, vLLM achieves up to 130K total tokens per GPU-second on DeepSeek V4 Pro, and an interactivity of up to 376 tokens per second on MiniMax M3. Across DeepSeek V4 Pro, MiniMax M3, and Kimi K3, vLLM delivers a 14.6×–106× serving-cost advantage over Opus 5 API pricing (see Performance).