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Dima Bolkunov argues against relying on AI to write text for others: AI averages away an author's style and the empathy it enables, loses precision because it must fill gaps with ambiguous wording, removes the self-critique that writing forces, and shifts effort from writer to reader, so the writer's time savings evaporate on the readers' side.
2 min · 409 words
Superhuman Hardware Design Is The Easy Part
a16z partner Christian Keil argues frontier AI models will soon become superhuman at hardware design, but that the lossy interface between digital designs and physical atoms means building, testing, measuring and iterating real hardware will lag, shifting the frontier to manufacturing, procurement, data capture and process knowledge held by technicians.
12 min · 2,770 words
How Claude designed protein binders against scorpion neurotoxins
Anthropic describes asking an internal research Claude model, with prompts developed alongside Citrini Research, to design minibinders against scorpion neurotoxins as a step toward antivenom. Adaptyv Bio and Twist Bioscience tested 211 designs for binding and 17 met the criteria; the post covers the workflow, results, remaining steps to a treatment, and the open release of all designs and data.
11 min · 2,462 words
Academics have a duty to defend open knowledge systems like Wikipedia
Helen Choi of the University of Southern California argues that generative AI products are diverting readers from Wikipedia and misappropriating volunteers' work, threatening the community that sustains it. She contends academics, as researchers and teachers, have an ethical duty to defend open knowledge communities, and that universities should recognise and resource contributions to Wikipedia.
5 min · 1,129 words
Gamow Labs introduces LabRobotBench, a benchmark that uses an in-silico simulation of its robotic wet lab to test whether frontier AI agents can diagnose equipment failures and safely recover interrupted experiments such as cell assays and dose-response runs; GPT 6.1 Sol scored 46.7%, Opus 5.5 23.0% and Gemini 4 Argon 20.9%.
4 min · 940 words
Steve Krouse, a programmer and soon-to-be father, asks what education is for in the age of AGI. Drawing on Neil Postman's The End of Education, Edison's failed prediction that technology would replace teachers, and the Lindy effect, he reflects on why schools endure, how AI undermines 'earning a living' as a purpose, and proposes crafting education's purpose together with children.
4 min · 993 words
To Make, or to Buy: The Economics of Decision Models
Parth Parikh explores the economics of decision models like Jev, whose outputs are choices, scores or abstentions rather than free text, formalizes decision hierarchies using Chow's reject rule to decide when a cheap model should defer to a costlier one, and speculates on multimodal and on-device uses.
16 min · 3,592 words
There's little that's "inevitable" about AI
Iris Meredith of deadSimpleTech examines the common claim that AI is inevitable, asks what that would actually mean for a technology, and argues that by the boosters' own implicit standards of cost, adoption and durability, large language models fall well short of being inevitable.
16 min · 3,794 words